The 49th Operations Group supports national security objectives, as directed by the Joint Chiefs of Staff, by training U.S. Air Force and allied aircrews in MQ-9 pilot and sensor operator upgrade training as well as instructor and fighter weapons instructor courses. The 49th Operations Group is comprised of four squadrons, including the 6th Attack Squadron, 9th Attack Squadron, 29th Attack Squadron, 16th Training Squadron. The 49th Operations Group also oversees two geographically separated units to include the 491st Attack Squadron located at Hancock Field Air National Guard Base, New York, and the 492nd Attack Squadron located at March Air Reserve Base, California.

The 49th Maintenance Group maintains F-16 Fighting Falcon and MQ-9 Reaper aircraft along with associated Ground Control Stations in the Air Force's largest flying training operation.  The group also provides maintenance support M1 contract maintained T-38 aircraft.  The 49th Maintenance Group directs all maintenance qualification, on-the-job and ancillary training for 700 Airmen, civilians, and contract personnel, managing over $5.5 billion in aircraft and equipment.  Finally, the group also supports flying activities, exercises and worldwide taskings as assigned by the Combatant Commanders and the Secretary of Defense against high value targets.